Many experts and analysts in the field of political and economic affairs believe that crisis of Syria not only was domestic struggles, but also was a field for contradiction with benefits of different countries. The aforesaid crisis due to having domestic, national and international complexities is regarded as center of global attention. In fact, Syria is regarded as small world in the Middle East and war in Syria was called as the begin for World War that was began by U.S.A, now the question is that is this war ends with U.S.A as well? As global crisis greatly influences on different countries, the Syria crisis influences on different countries as well. The Syrian crisis leads to going to astray in diplomatic relations of countries, convergence in region, turning old friend to most important enemies and enemies to possible friends in future. American people believe that, America never has permanent friend and enemy, rather the criterion for being friend or enemy is only benefits of America. If during the recent evolution in Middle East except Syria in the remained crisis the global superpowers specially U.S.A was only observer and in order to maintain its appearance and prevent from direct intervention, this issue was not correct for Syrian crisis. In fact, from the first days of Syrian crisis we observed strong participation of such countries specially U.S.A and its allies and Russia. Sending money, weapon, mass media assistance shows field evolutions, dispatching military lieutenants, intelligence service officers, spy satellites over Syria, dispatching terrorist to war of Afghanistan, Alqada terrorist group, Salafi and Wahhabism under supervision of Saudi Arabia government, presence of terrorists from Europe, Asia and terrorists from other African countries are all instances of pressure over people and country that intends to be determined for obtaining its national benefits. Otherwise, the plan of Large Middle East and several wars during recent decades in the Middle East only refers dominance of Israel on world. In fact, dominance over Middle East paves the way for dominance over other countries. Awakening countries and high energy of Islamic countries is regarded as serious impediment for progress of this plan. In this article, it is attempted to study the basics and consequences of intervention of the U.S. on Syrian crisis and some field observations in Syria over Middle East and other regions.